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Pilot study of a compassion meditation intervention in chronic pain

Last updated: 07-22-2020

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Pilot study of a compassion meditation intervention in chronic pain

Journal of Compassionate Health Care
Pilot study of a compassion meditation intervention in chronic pain
Heather L Chapin 1 ,
Beth D Darnall 1 Email author ,
Emma M Seppala 2 ,
Jennifer M Hah 1 and
Sean C Mackey 1
©  Chapin et al.; licensee BioMed Central Ltd. 2014
Received: 27 March 2014
Abstract
Background
The emergence of anger as an important predictor of chronic pain outcomes suggests that treatments that target anger may be particularly useful within the context of chronic pain. Eastern traditions prescribe compassion cultivation to treat persistent anger. Compassion cultivation has been shown to influence emotional processing and reduce negativity bias in the contexts of emotional and physical discomfort, thus suggesting it may be beneficial as a dual treatment for pain and anger. Our objective was to conduct a pilot study of a 9-week group compassion cultivation intervention in chronic pain to examine its effect on pain severity, anger, pain acceptance and pain-related interference. We also aimed to describe observer ratings provided by patients’ significant others and secondary effects of the intervention.
Methods
Pilot clinical trial with repeated measures design that included a within-subjects wait-list control period. Twelve chronic pain patients completed the intervention (F = 10). Data were collected from patients at enrollment, treatment baseline and post-treatment; participant significant others contributed data at the enrollment and post-treatment time points.
Results
In this predominantly female sample, patients had significantly reduced pain severity and anger and increased pain acceptance at post-treatment compared to treatment baseline. Significant other qualitative data corroborated patient reports for reductions in pain severity and anger.
Conclusions
Compassion meditation may be a useful adjunctive treatment for reducing pain severity and anger, and for increasing chronic pain acceptance. Patient reported reductions in anger were corroborated by their significant others. The significant other corroborations offer a novel contribution to the literature and highlight the observable emotional and behavioral changes in the patient participants that occurred following the compassion intervention. Future studies may further examine how anger reductions impact relationships with self and others within the context of chronic pain.
Keywords
Compassion Meditation Anger Chronic pain Women
1 Background
Chronic pain affects an astounding 100 million Americans - causing suffering for the individuals afflicted, their families, and significant others. Chronic pain also exerts a significant financial burden on the U.S. economy, costing over half a trillion dollars annually [ 1 ]. The relationship between pain and psychosocial factors suggests that pain involves dynamic interactions between the mind/brain, body, and environment [ 2 ],[ 3 ]. As such, chronic pain can negatively impact a person’s cognitive and emotional state [ 4 ],[ 5 ] as well as their relationship with themselves [ 6 ] and others [ 7 ]–[ 10 ]. Conversely, pain also may be inhibited or facilitated by various cognitive, emotional, and contextual factors that influence ascending and descending neural pathways [ 11 ]–[ 13 ], suggesting that effective cognitive and emotional interventions may positively influence these pathways and reduce pain.
Anger is an important emotional correlate of chronic pain [ 6 ],[ 14 ]–[ 25 ], with studies showing that chronic pain is associated with anger and animosity towards others as well as towards oneself [ 6 ],[ 19 ],[ 23 ] including disappointment and frustration with pain [ 26 ], self-blame [ 27 ], self-criticism [ 28 ] and poor acceptance of one’s physical limitations [ 29 ]. Furthermore, anger is associated with reduced pain treatment response [ 9 ],[ 30 ] and impaired relationships with spouses [ 10 ]. Accordingly, we investigated a mind-body intervention—compassion meditation-- to address both pain and anger.
Compassion is the experience of perceiving suffering and wishing to alleviate that suffering. We selected compassion meditation because compassion – which this meditation is meant to train – is shown to increase psychological well-being and interpersonal relationships. Compassion is linked to less judgmental views of others [ 31 ], greater life satisfaction [ 32 ], decreased anxiety, depression, and chronic distress, and positive emotions as a consequence of compassionate acts [ 33 ]. Individuals with greater compassion experience better relationships and are regarded by others more positively [ 34 ]. Compassion meditation is prescribed as treatment for persistent anger in Eastern cultures [ 35 ].
Strengthening compassion is not a new concept in Eastern contemplative traditions, which have meditation practices devoted specifically to cultivating feelings of loving-kindness and compassion. Through the recognition of a common humanity, these practices involve the development of feelings of love and compassion that are directed to the self, others, and ultimately towards all beings [ 36 ]. Despite the rich history of these established practices in contemplative traditions, compassion training is a relatively new area of study in the Western world [ 37 ] (review).
Compassion meditation is based on broader, general meditation practices, which have been shown to be effective for reducing a wide variety of negative cognitive and emotional state--and psychopathology such as anxiety and depression [ 38 ],[ 39 ]. Meditation-based interventions have few if any side effects [ 40 ],[ 41 ], are cost- and time-effective [ 41 ]–[ 43 ], and provide patients – who learn tools to help themselves - with a sense of autonomy [ 43 ] and self-mastery [ 44 ].
In compassion meditation training participants learn to experience feelings of compassion while meditating on various relationships (e.g., self, partner, difficult people, strangers). Accordingly, the intention of compassion meditation training is to increase a person’s capacity to experience compassion for themselves, others, and the world [ 45 ]. Compassion may be cultivated through training [ 46 ]–[ 48 ] and has longitudinal effects, with gains in compassion maintained at one year follow-up [ 47 ]. Compassion-focused therapeutic interventions [ 49 ],[ 50 ] have been shown to reduce depressive symptoms in various populations [ 51 ]–[ 53 ]. Compassion interventions are also associated with increased positive emotions [ 54 ], feelings of social connectedness [ 55 ], pro-social behavior [ 56 ] and improved health outcomes in the form of optimized immune and stress responses [ 57 ]. Within the context of chronic pain, self-compassion has been associated with greater chronic pain adaptation and acceptance [ 58 ]. Because of its effect on decreasing anger and increasing self-compassion and interpersonal compassion, compassion meditation may particularly benefit for individuals with chronic pain.
Indeed, prior work on interpersonal relationships has shown heightened distress and marital dissatisfaction in the spouses of people with chronic pain [ 7 ]. The marital dissatisfaction appears to be partially mediated by the level of emotional distress of the person with pain [ 7 ]. Of particular interest is the finding that anger and hostility in individuals with chronic pain predicts depression and marital satisfaction in their spouses [ 10 ]. Furthermore, anger in individuals with chronic pain also has specific discriminative value: studies of emotion profiles have shown that anger distinguishes healthy individuals from those with chronic pain and further discriminates between depressed individuals and those with chronic pain [ 59 ]. As such, interventions that specifically target anger may hold value for treating chronic pain, distress related to pain, and distress in the spouses and significant others of those living with chronic pain.
We found only one study that examined the effect of a compassion-based intervention -- loving-kindness meditation training—on chronic pain [ 24 ]. In this study individuals with chronic low back pain were randomized to either standard care or to the 8-week compassion-based meditation program that was specifically adapted for chronic pain through inclusion of a chronic pain didactic component. Compared to the usual care group, participants who received the intervention had post-treatment reductions in pain, distress, anger, and tension. Of interest, same-day pain and next-day anger were negatively correlated with the amount of time spent practicing loving-kindness meditation, suggesting a dose-dependent relationship with the meditation practice. Overall, the study provided evidence that a compassion-based meditation may improve pain and anger in individuals with chronic pain; however, the inclusion of the pain didactic component in the intervention introduced a confound that precluded clear understanding of the unique effect of the compassion-based meditation on pain and anger. Furthermore, we found no study to date to the effect of a compassion intervention on chronic pain acceptance.
The purpose of this pilot study was therefore to investigate whether a general compassion cultivation intervention—devoid of pain didactics – would improve pain, anger, and pain acceptance in individuals with chronic pain, and to test whether improvements would be corroborated by the 3rd person observation of their significant others. Our primary hypothesis was that compassion cultivation in individuals with chronic pain would result in reduced pain intensity and anger. We also hypothesized that the intervention would associate with reduced pain-related interference in various life domains and increased pain acceptance. Finally we hypothesized that reductions in anger and pain interference in individuals with chronic paina would be corroborated by significant other report [ 60 ].
2 Methods
In this pilot study we used a within-subjects, wait-list control with repeated measures design to characterize the effects of a compassion meditation intervention on chronic pain patients and their significant others. A link to an online questionnaire was emailed to all patients at three time points: at enrollment, after a 5-week post-enrollment waiting period (treatment baseline), and again after completion of the 9-week compassion training course (post-treatment); see Figure  1 for an illustration of the study timeline. Throughout the duration of the compassion cultivation intervention patients completed an online daily compassion meditation log to quantify the minutes they spent meditating that day.
Figure 1
Study timeline.
During the 5-week waiting period, patients were instructed to simply “live their lives as they normally would”. This design allowed patients to serve as their own wait-list controls. Lack of significant differences between enrollment and treatment baseline time points would lend confidence that any observed post-treatment changes would be attributable to the compassion intervention rather than to time effects (e.g., regression to the mean). To produce a rich and maximally informative dataset, we utilized a mixed-methods approach including both quantitative questionnaire data and qualitative interview and survey data.
Interviews were conducted in-person at the enrollment visit and surveys were administered online at treatment baseline and post-treatment following the last compassion class (described below). The patients’ significant others completed interviews at the same time points as the chronic pain patients. Significant others were not allowed to attend the compassion cultivation intervention because we were specifically interested in the observer reports of the significant others, and in any secondary effects of the compassion intervention. All patients and patients’ significant others provided written, informed consent as approved by the Stanford University Institutional Review Board.
2.1 Chronic pain patient participants
Patients with chronic pain (N = 119) were contacted from a database of individuals with chronic pain that had previously expressed interest in research participation at the Stanford Systems Neuroscience and Pain Lab. Figure  2 displays the participant flow chart and describes the inclusionary and exclusionary criteria for the study. Twenty-eight chronic pain patients attended the information session and were enrolled in the study (24 female, mean age = 49.61, SD = 10.59). Figure  2 describes the reasons for participant drop out or withdrawal from the study (N = 14). The twelve patients who completed the study were included in the analytic dataset (F = 10; mean age = 48.33, SD = 10.80) (See Table 1 ).
Figure 2
Low back, widespread pain (fibromyalgia)
13.0
22.0
2.2 Significant other participants
Patients were asked to identify a significant other to participate with them in the study -- someone with whom they had a close relationship and interacted with frequently (e.g., spouse or life partner, girlfriend or boyfriend, family member, or close friend). Patients then asked their significant others to contact the lab to be screened over the phone and schedule a time to attend an initial information session with their chronic pain study partner. Significant others were included if they were 18 years of age or older and excluded if they were diagnosed with a major psychiatric disorder, reported having a substance abuse problem in past 24 months, or had prior compassion meditation training. All significant others of the enrolled patients were eligible and provided informed consent (N = 28, 7 female, mean age = 50.71, SD = 12.59). Only the significant others of patients who were retained in the study were included in the final analysis (N = 12; 3 female, mean age = 49.17, SD = 11.48). Significant others’ demographics and relationships to the patients are shown in Table  2 .
Table 2
Significant other demographics & relationship to patient
ID
Caucasian
Husband
The significant others did not receive the compassion cultivation intervention. Rather, the role of the patients’ significant others was to provide pre- and post-treatment observer information about their chronic pain patient partners.
2.3 Compensation
All enrolled chronic pain patients and their significant others each received $35 at the initial information session and were mailed $50 checks after completion of the last battery of questionnaires and final post-course survey questions. In addition, the chronic pain patients received the Compassion Cultivation Training (CCT) course at no cost to them.
2.4 Compassion cultivation training course
Chronic pain patients attended a standardized 9-week CCT course developed by Stanford’s Center for Compassion and Altruism Research and Education (CCARE). The intervention was delivered to all patients simultaneously in a single class cohort. An experienced CCT instructor who was certified through CCARE’s instructor training program taught the course. To ensure that no pain didactics were delivered during the class, the instructor selected for the study had no formal pain training or background delivering the intervention to patients with chronic pain.
The course involved weekly 2-hour class meetings that included didactics specific to compassion meditation practices, in-class meditation practice, and small and large group discussions. Patients were also given a CD containing all of the guided meditations. A class website provided an optional forum for patients to discuss their experiences involving their in-class or at-home practice. The instructor posted on the website audio recordings of meditations that were themed for the week and any materials that were discussed in class. The website was available only to the patients and no data were collected from their in-class or online discussions. Significant others were not allowed to attend the course with the patients, and patients were asked to not share with their significant other any material from the class (e.g., audio recordings of guided meditations).
As a foundation for compassion meditation training, the first 2 classes involved basic instruction in mindfulness meditation. The compassion meditation training began in week 3 with a practice centered on cultivating feelings of compassion for someone with whom they had a close relationship. Weeks 4 and 5 were devoted to developing self-compassion, week 6 to developing compassion for strangers, and week 7 focused on cultivating compassion for difficult people through the recognition of a common humanity. In week 8, chronic pain patients were taught a “Tonglen” meditation practice, in which they learned to imagine taking in suffering (either in general or from a specific person) on the in-breath and release suffering on the out-breath. The class closed in week 9 with suggestions on how to continue to integrate compassion practices into their daily lives. Over the 9-week period, patients were asked to keep a daily online record tracking the number of minutes of meditation they practiced. Patients were provided additional, optional homework exercises related to the compassion theme each week (e.g. writing a compassionate letter to oneself).
2.5 Variable measurement
2.5.1 Chronic pain patients
Anger
The Patient Reported Outcomes Measurement Information System (PROMIS) Anger Scale [short form, [ 61 ] includes 8 items for which respondents rate their frequency of angry feelings and reactions experienced over the previous 2 weeks using a 5-point scale (e.g., I was irritated more than people knew, 1 = never, 5 = always). PROMIS Anger has been used in chronic pain research [ 62 ].
Pain severity
Pain severity was calculated as an average of four questions of the Brief Pain Inventory short form [BPI, 63] in which respondents rate their worst, least and average pain over the past week, as well as their current pain severity. All items use an 11-point response scale (0 = no pain, 10 = pain as bad as can imagine).
Pain-related functional interference
Pain Interference was also measured by the Brief Pain Inventory Short Form [ 63 ]. Seven items assess to what degree pain interferes with functioning in 7 life domains (general activity, mood, walking ability, normal work, relations with other people, sleep, and enjoyment of life) on an 11-point scale (0 = does not interfere, 10 = completely interferes). The ratings for the 7 items were averaged to create a composite pain-related functional interference score.
2.6 Chronic pain acceptance
Pain acceptance was measured with the Chronic Pain Acceptance Questionnaire [ 58 ], a 20-item self-report questionnaire in which respondents use 7-point scale (0 = never true, 6 = always true). Sample item: “I am getting on with the business of living no matter what my level of pain is.” Higher scores are indicative of greater pain acceptance and adaptive adjustment to chronic pain.
Patients and significant others were asked to refrain from discussing their survey responses with one another. All questionnaires were presented in random order for all patients. Questionnaires were distributed and completed through the Stanford University online survey system (Qualtrics, Provo, UT, http://www.qualtrics.com/ ) which meets the Health Insurance Portability and Accountability Act (HIPAA) compliance standards.
2.7 Semi-structured interviews/surveys
2.7.1 Enrollment chronic pain patient interview
Patients and Significant Others completed an in-person, semi-structured interview with study staff at study enrollment. The interview contained quantitative and open-ended questions. The purpose of the enrollment interview was to collect information about patients’ past meditation experience and expectations about the study. Open-ended questions asked about their past meditation experience and any current meditation practices. Only specific experience with compassion meditation was exclusionary for the study. In terms of treatment expectations, patients were asked how much they expected the compassion intervention would improve their pain and quality of life on a 0–10 scale (0 = no improvement, 10 = complete improvement.)
2.7.2 Enrollment significant other interview
The significant others were asked to rate how much they expected the course would improve their partner’s pain (0 = no improvement, 10 = complete improvement) and their partner’s quality of life (0 = no improvement, 10 = complete improvement). Open-ended questions asked significant others about their past meditation experience and any current meditation practices.
2.8 Post-treatment online survey
2.8.1 Patient post-treatment online survey
Immediately following the last class, all patients were emailed a link to the online post-treatment survey that consisted of both quantitative and open-ended questions. Patients were asked to rate on a 0–10 scale how much they thought the course improved their pain and quality of life (0 = no improvement, 10 = completely improved). If they rated > 0 improvement, patients were then asked open-endedly which aspects of their quality of life they felt were changed as a result of the compassion intervention. Additionally, patients were asked whether they thought the intervention changed the way they relate to themselves, to their significant others, and to the outside world, and if so, to provide examples.
2.8.2 Significant other post-treatment online survey
Immediately after their partner completed the compassion intervention, each significant other received a link to the post-treatment survey. Significant others were asked to rate how much they thought the course improved their chronic pain partner’s pain and quality of life (0 = no improvement, 10 = completely improved). If they rated > 0 improvement, they were asked open-endedly which aspects of their partner’s life were improved by their chronic pain partner having participated in the compassion intervention. Finally, they were asked whether they observed changes in the way their patient partner related to themselves, to them (the significant other), or to the outside world, and if so, to provide examples.
2.9 Analysis
One-way repeated measures analysis of variance (RM-ANOVA) tests were conducted for each questionnaire using SAS Version 9.4 (SAS Institute Inc., Cary NC) with time as the repeated measures factor. Where significant main effects were found, post hoc paired t-tests were calculated to determine which time points differed significantly (e.g., pre- compared to post-course time points). The primary outcome measures were BPI Pain Severity and PROMIS Anger, with BPI Pain Interference and Pain Acceptance as secondary outcomes. Pearson correlation was used to examine relationships between time spent in compassion meditation and the change in score from pre-course to post-course of the primary and secondary outcomes. In regression analyses, time spent in compassion meditation was examined as a predictor (process) variable. Secondary outcomes were corrected for multiple comparisons using a False Discovery Rate correction (corrected minimum p value needed for significance = .024). All other measures were exploratory and were not corrected for multiple comparisons given the small sample size. Technical difficulties prevented the Pain Acceptance questionnaire from displaying properly in the online system at baseline for half of the patients. Therefore, a paired t-test was conducted to determine changes in pre- to post-course Pain Acceptance because data was available for all 12 patients at both of these time points.
3 Results
3.1 Chronic pain patients
No differences were found between participants who completed the study and those who withdrew or were withdrawn in terms of our primary measures (Pain Severity, Pain Interference, or anger).
3.1.1 Questionnaires
Table  3 displays the results for each measure across the study time points. As expected, we found no significant differences between enrollment and treatment baseline ratings for any of the primary measures (BPI Pain Severity, PROMIS Anger score) with post-hoc paired t-tests. As such, the remainder of the results describe the RM ANOVA results and subsequent contrast between the pre- and post-treatment time points. As hypothesized, a significant difference existed across all time points for BPI pain severity (Table  3 ). BPI Pain Severity was significantly reduced at post-treatment compared to enrollment and treatment baseline; t(11) = 3.75, p = 0.003 and t(11) = 2.45, p = 0.03 respectively (See Figure  3 ). Similarly, a significant difference existed across all time points for PROMIS Anger score (Table  3 ). PROMIS Anger score significantly decreased at post-treatment compared to enrollment and treatment baseline; t(11) = 2.67, p = 0.02 and t(11) = 2.92, p = 0.01 respectively (See Figure  4 ). Additionally, paired t-tests showed significant improvements for Pain Acceptance pre- to post-treatment; t(11) = −2.94, p = 0.01).
Table 3
* Results reported as Pearson product–moment correlation coefficient (p-value).
§ Significant correlation (p-value


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